No image available
No image available
Your request is being processed.

Custom Chromatography Media

If the chromatography media (resin) you require is not part of our standard product offering, our specialists can custom design your chromatography medium from an appropriate base matrix and ligand.

For over 20 years, we have provided BioProcess customers worldwide with custom designed chromatography media suitable for large-scale and GMP-regulated manufacturing of biopharmaceuticals. Many of our custom media have later become part of our standard product offering such as Capto Phenyl, Capto Butyl, and KappaSelect.

We work with you to develop and produce custom combinations that fulfill your requirements regarding binding capacity, selectivity, and regulatory support documentation. We give you the flexibility to choose your own ligand, one of our ligands, or a third party ligand.

For more information about custom chromatography media, please contact your local GE Healthcare representative.

Base Matrices & Ligands Project Model Available Custom Chromatography Media

The key components of any chromatography media is the combination between the Base matrix, Ligand, and Coupling chemistry. Together, these parameters are the foundation for high selectivity, capacity, and pressure/flow properties which is the basis for cost-effective purification.

Our custom specialists have access to all of GE Healthcare Life Sciences’ base matrices, for example Capto and Sepharose Fast Flow matrices. Each base matrix has its own profile in terms of pore and bead size, where the optimal choice can be combined with the relevant ligand for your application and process.

Project Model & Documentation


- Technical discussion under a CDA*

- Developement of small scale prototypes under an MTA**

- Prototype evaluation by the customer

- Mutual evaluation of the potential for a new product "stop or go" decision

- Evaluation of robustness in the synthesis at GE and performance in the customer process

- Setting a product specification that allows for a robust and high performing production on both sides

- Developing analytic methods for QC testing at GE

- Pilot scale deliveries from us to the customer

- Scale up to the required process scale

- Validation of the process- Developing a Regulatory Support File

- Full scale deliveries




* Confidential Disclosure Agreement

** Material Transfer Agreement

Available Custom Chromatography Media for Evaluation

Product /Project Article number Application area Status
KappaSelect 17-5458-00 Purification of Kappa Fab fragments Launched product
LambdaFabSelect 17-5482-00 Purification of Lambda Fab fragments Launched product
VIISelect 17-5477-00 Purification of Factor VII Launched product
VIIISelect 17-5450-00 Purification of Factor VIII Launched product
IXSelect 17-3714-00 Purification of Factor IX Launched product
Alpha1AntitrypsinSelect 17-5472-00 Purification of Alpha 1 Antitrypsin Launched product
AVB Sepharose HP 28-4112-00 Purification of adeno associated viruses Launched product
Capto Blue (high sub) 17-5452-00 Misc pseudo affinity targets Late stage project
Capto Q XP 17-5473-00 Purification of large proteins (IgG) Mid stage project
MacroCap Q 17-5469-00 Purification of very large proteins (e.g., PEGylated proteins) Launched product
Plasminogen Removal Gel 28-4109-00 Purification of plasminogen by affinity Late stage project
Capto Heparin 17-5462-00 Purification of misc enzymes and proteins Launched product
Capto Octyl 17-5465-00 Purification of misc proteins Launched product
Capto ImpRes Phenyl 17-5484-00 Purification of misc proteins Launched product